Annotated Bibliography: Patients with Opioid Induced Constipation Resolved with Supplements or Suppositories Lionell H. Edwards Chamberlain College of Nursing NR 500 Foundational Concepts and Application Annotated Bibliography: Patients with Opioid Induced Constipation Resolved with Supplements or Suppositories Na, J. , Oh, K. , Park, S. , Bae, D. , Choi, E. J. , Jung, M. A. , & … Kim, S. (2013). The laxative effects of Maesil (Prunus mume Siebold & Zucc. ) on constipation induced by a low-fibre diet in a rat model.
International Journal Of Food Sciences & Nutrition, 64(3), 333-345. doi:10. 3109/09637486. 2012. 38648 Believing a fruit substance has medical properties to resolve constipation in rats, the author of the article performs a research study using “Maesil” a fruit compound of Prunus mume Siebold & Zucc. The experiment as the author described is a vitro experiment that will measure the colon contractions producing increases in stool in rats. through the experiment, the author concluded that Maesil was effective in relieving constipation and increasing the contraction of a rat’s colon. The article gave insight that the use of natural products such as plants may have an substantial credit in relieving constipation.
Dhingra, L. , Shuk, E. , Grossman, B. , Strada, A. , Wald, E. , Portenoy, A. , & … Portenoy, R. (2013). A qualitative study to explore psychological distress and illness burden associated with opioid-induced constipation in cancer patients with advanced disease. Palliative Medicine, 27(5), 447-456. doi:10. 1177/0269216312450358 Using the objective in research, the author aim was to use an qualitative research methods to examine the psychological stressors related from opioid-induced constipation within a population involving cancer patients.
Presenting a design method, the authors utilized interview conducted within the study by examining reoccurring surrounding by examining a group of cancer patients in a hospital setting. Through the interview process, details were presented to indicate where stressors may occur. The results presented in the study recognized that educational may need to be provided to alleviate stress associated with opioid-induced constipation, psychological stress may be a contributor to the effects of opioid-induced constipation, and awareness of constipation to use opioidinduced constipation medications.
Overall the article presented factors to try to improve stress related issues associated with opioid-induced constipation. Twycross, R. G. , McNamara, P. , Schuijt, C. , Kamm, M. A. , & Jordan, C. (2006). Sodium picosulfate in opioid-induced constipation: results of an open-label, prospective, dose-ranging study. Palliative Medicine, 20(4), 419-423. doi: 10. 1191/0269216306pm11350a Though experimentation, the author examined participants ranging from 40 to 81 to determine appropriate dose range for a medication called sodium picosulfate a laxative from the description in the article.
During the experiment the medication stated was titrated to produce positive results needed to relieve the effects of constipation. Not all participant remained in the study due to health related reason as mentioned by the author, however the authors noted that for the remaining participant the medication was well tolerated and results were positive. With the use of the medication, the authors foresighted that the use of other products such as suppositories were eliminated and not needed to produce results.
From reviewing the article, the information presented was clear and easy to understand in accordance to nursing practice and may be justified as a need in daily practice. Kamm, M. A. (2003, August 30). Constipation and its management. BMJ: British Medical Journal (International Edition). pp. 459-460. Regarding the journal presented, the author examines a cross sectional study to indicate that psychological morbidity may be associated with constipation, however the author is aware that that there are times such when psychological issue may not be a factor and the physiology portion is a contributor as such with spinal cord related injuries.
As a solution for idiopathic such as cancer and other chronic causes related to injury the author presents Polyethylene glycol a laxative used in common practice including my place of work. The author concluded that the substance may be a supplemental medication that may resolve for temporarily relief of fecal impaction or constipation. Through the reading of the journal, the author present a straight forward description using the cross sectional study to present ways to manage various types of constipation. Leppert, W. (2015). Emerging therapies for patients with symptoms of opioid-induced bowel dysfunction.
Drug Design Development And Therapy, 92215-2231. Realizing that the prolong use of opioid medications cause Opioid-induced bowel dysfunction (OIBD), the author of the article expresses the leading root causes of disease processes that could cause the digestive to have slow mobility with the continuous use of pain analgesic medications. Highlighting traditional method utilized to treat opioid-induced constipation (OIC), the author reviews details related to laxative used in the past to treat OIC with no significant solution to the resolving OIC.
Present new method the author introduces a dual combination of an analgesic medication combining oxycodone with prolonged release medication naloxone. Given the combination of the combined medication called “OXN” the author points out that the substance would provide equally effective relief of OIC with less chronic condition of OIC. The author further present other medications that may increase the motility of the gut to cause patients to move their bowls efficiently reducing the chance of OIC. Poelaert, J. , Koopmans-Klein, G. , Dioh, A. , Louis, F. , Gorissen, M. , Loge, D. , & … van Megen, Y. B. (2015).
Treatment With Prolonged-Release Oxycodone/Naloxone Improves Pain Relief and Opioid-Induced Constipation Compared with ProlongedRelease Oxycodone in Patients with Chronic Severe Pain and Laxative-Refractory Constipation. Clinical Therapeutics, 37(4), 784-792. doi:10. 1016/j. clinthera. 2015. 02. 010 This article further points out details of how a combination of oxycodone and naloxone may reduce the effects of opioid induced constipation (OIC) in patients with chronic pain related issues or disease. Using a nonintervention observation study participants were assessed using the controlled substance to determine effectiveness.
Through the observation experiment showed that some patients indicated reduce pain with a significant reduction of OIC. The author contributed key components of the design study pointing out that the study was performed of a 12 week period and conducted under the rule of law regarding European health practice. Over the period of examination the participants in the case of the study were all over the age of eighteen. The results of the study concluded a significant in the quality of health after the use of the combined medication. Wein, S. 2012). Opioid-induced constipation. Journal Of Pain & Palliative Care Pharmacotherapy, 26(4), 382-384. doi: 10. 3109/15360288. 2012. 734907 Presenting the journal, the author gives explanation of what opioid-induced constipation (OIC) means. Through the content of the journal the author gives back ground of what causes OIC such as the effect that opioid medications have of the anatomy of the digestive system slowing the motility, causing pain, along with other complication such as hard stool, impaction and many other discomforts presented.
After pointing out the mechanic of what causes OIC, the author expresses solutions that would alleviate the slowing of the bowel while using opioid medications such oral laxatives such as senna, sodium docusate or such medications as a osmotic laxative such as sorbitol or latulose. The author continues on to present the use Magnesium hydroxide, and Polyethylene glyco as a temporarily relief of hardening stool. Moving on, the author details the use of suppositories and their methods explaining details related the types of suppositories to use related to soft and hard stool.
The author stresses that supposiotories may be a contributing factor regarding dehydration and that a person using such application should maintain hydration precautionary measures. Material presented in the journal was useful as far a reference related to the root cause of OIC and usage to resolve. Fernandes, A. W. , Kern, D. M. , Datto, C. , Yen-Wen, C. , McLeskey, C. , & Tunceli, O. (2016). Increased Burden of Healthcare Utilization and Cost Associated with Opioid-Related Constipation Among Patients with Noncancer Pain.
American Health & Drug Benefits, 9(3), 160-169. Using a cohort study to examine utilization cost over a 12 month review, the authors of text present details to assess the ever growing spending cost associated with opioid-induced constipation (OIC) regarding increase hospital stay. The population present range from eighteen and older during the time period between January 2006 until June 2014 and was conducted with related and non related patient with and without OIC during a twelve month period.
As for the results, it was determined that users of opioid medication were most likely double the risk of being subject to hospital stay. Through experimentation the percentage cost were substantial higher for participants receiving opioid medication compared to those that were not. Given the conclusion, the authors determined that through the cohort study that there was a significant in increase associated with patient experiencing OIC. Owens, G. M. (2016). Can Improved Management of OpioidInduced Constipation Mitigate the Associated Costs?.
American Health & Drug Benefits, 9(3), 170. To further iterate on the previous cohort study performed associated with increase cost and hospitalization, a brief article by the author ask the question could management of cost be reduce associated OIC. In the article, the author points out that millions of prescription were prescribed during the year of 2013 and during that time period an increase from fifteen to ninety five percentage regarding patients with OIC had increased.
Regarding dollar amount the author estimated an increase healthcare cost of approximately $12,413 per each individual with OIC stressing in the article that there is a significant increase in the United States that has a greater affect on tax payer’s dollars. Coyne, K. S. , LoCasale, R. J. , Datto, C. J. , Sexton, C. C. , Yeomans, K. , & Tack, J. (2014). Opioid-induced constipation in patients with chronic noncancer pain in the USA, Canada, Germany, and the UK: descriptive analysis of baseline patient-reported outcomes and retrospective chart review.
ClinicoEconomics and Outcomes Research: CEOR, 6, 269-281. http://doi. org/10. 2147/ CEOR. S61602 Given the experiment of the related article a longitudinal study was performed and conducted examining an ongoing review of the USA, Canada, Germany, and the United Kingdom related to OIC as the author concerns stem from the ever increasing amount of opioid use in the areas mentioned. Through the research many areas were examined to retrieve the data needed for the research such as surveys, chart reviews, and physician questionnaires.
Including in the study patient questionnaires were obtained along with many other associated questionnaires. After all the data was collected a statistical analysis was performed for adjusted needed in the research. The results concluded that the quality of life of the individual in the study had significantly change related to OIC and adjustment regarding the diagnosis were now a factor in controlling and managing the use of opioid medication and performing adjustment to relieve the symptoms of OIC.