Caffeine and Cognition Write-Up
1: Which data sets have you selected for your analysis? (5% of mark)
The question being considered is the “battle of the sexes” and whether males or females are better at speech-based tasks (this study used the Stroop test). The second question is whether or not caffeine improved the performance of participants in the speech based tasks.
Data sets used:
V1(Sex of participant), V3(What was the drink taken), V23 (Stroop test-time taken to read word) and V24 (Stroop test-time taken to read colour)
2: What is the background of your study? (25% of mark)
Caffeine is one of the most commonly used CNS stimulants (1). Cytochrome P450 oxidase metabolises caffeine to Paraxanthine, Theobromine and Theophylline (2). Caffeine acts as a competitive inhibitor of adenosine…
Institute of Medicine (US) Committee on Military Nutrition Research. Pharmacology of Caffeine. Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. 1:25-31, 2001.
2. Tassaneeyakul, W., Birkett, D.J., McManus, M.E., Wongwiwat Tassaneeyakul, W., Veronese, M.E., Andersson, T., Tukey, R.H. and Miners, J.O. Caffeine metabolism by human hepatic cytochromes p450: Contributions of 1A2, 2E1 and 3A isoforms. Biochemical Pharmacology. 47: 1767-1776, 1994.
3. Daly, J.W., Butts-Lamb, P. and Padgett, W. Subclasses of adenosine receptors in the central nervous system: Interaction with caffeine and related methylxanthines. Cellular and Molecular Neurobiology. 3:69-80, 1983.
4. Porkka-Heiskanenf, T., Alanko, L., Kalinchuk, A. and Stenberg, D. Adenosine and sleep. Sleep Medicine Reviews. 6:321–332, 2002
5. Elmenhorst, D., Meyer, P.T., Winz, O.H., Matusch, A., Ermert, J., Coenen, H.H., Basheer, R., Haas, H.L., Zilles,K. and Andreas Bauer, A. Sleep Deprivation Increases A1 Adenosine Receptor Binding in the Human Brain: A Positron Emission Tomography Study. The Journal of Neuroscience. 27:2410 –2415,…