Trenbolone, an esterified form of testosterone, caused Frank’s testicles to shrink because the steroid trenbolone produces three times the effects of testosterone, making the body appear larger and performing certain roles of the testosterone, yet lacking the actual testosterone needed for the body to properly function. Since the testosterone was replaced by the trenbolone, sperm production decreased, shrinking his testicles.
To test the hypothesis, two males, both 20 years old and of the same build and weight, will be given the same workout to complete for a month, along with the same meal plan. One male will be given trenbolone and the other will male will not be given any steroid. Throughout the month, every seven days, both males will take their measurements of body fat, muscle, hair growth, weight and circumference of certain areas such as biceps and thighs. Following the end of the month, each male will also take a blood test to analyze the levels of testosterone in their bodies. The blood test will reveal GnRH, LH, and FSH levels.
To counteract the trenbolone acetate, which limits the release of LH (luteinizing hormone) and FSH (follicle stimulating hormone) the users can inject themselves with human chorionic gonadotropin, which has a similar structure to LH and FSH. This treatment may work because since there is no testosterone activating the receptors to release the hormones, chemically injecting them would allow for the hormones to pass through the body and function as if they were released naturally. With the manual injection of the hormones, it may supply the needed amount to offset the side effects since the hormones that testosterone help release that were missing, are not present.
For men who have gone through testicular cancer and have had one of their testicles to be surgically removed, the remaining testicle will increase, almost twice as large. The increase in growth of the testicle is due to the remaining testicles trying to compensate and function as if there were still both. Since the testicle is trying to compensate for both, it results in the over-production of sperm, testosterone, and male hormones. The brain, specifically the pituitary gland which releases the hormones such as LH, testosterone and FSH, asks for more production from the singular testicle.